Emergency services including paramedics, police and fire crews were called to the Newell Highway, near the Pilliga Forrest, just before 8am after reports two vehicles had collided.

The crash occurred near the intersection of Kerringle Road, about 60km south of Narrabri, and forced the closure of the highway as emergency services worked to help the patients at the scene.

A spokesperson for Ambulance NSW said paramedics arrived on scene to find one man trapped in his cabin.

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Together with rescuers they worked to free the 48-year-old man from the wreckage.

He was treated at the scene for lower leg injuries, the spokesperson confirmed.

Due to the nature of his injuries, the Westpac Rescue Helicopter was tasked from Tamworth to the scene and the chopper's critical care medical team assessed the patient.

He was then flown to Tamworth hospital and was believed to be in a stable condition.

Two other patients were treated at the scene for minor injuries by paramedics.

Both were then transported by road ambulance to Narrabri hospital. Both were in a stable condition.

The highway reopened shortly after 10am, after the scene was cleared.

The cause of the crash is being investigated by police.

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