Anne-Marie Munro has not been seen or heard from since Friday night, and those close to her have said it's completely out of character.
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Deeply concerned, they've called Hunter Valley police who are now appealing for the community's help to locate the 20-year-old.
Also known as Annie, she was reported missing when she didn't return home on Moore Close at Singleton on Saturday.
She was last seen in the Singleton area around 8pm on Friday and has not been seen or heard from since.
Annie is described as being of Caucasian appearance, about 160cms tall, of medium build, with brown hair and brown eyes.
She was last seen wearing a white striped t-shirt, dark pants and black shoes, carrying a jacket and black backpack.
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Also known as Annie, she was reported missing when she didn't return home on Moore Close at Singleton on Saturday.
Anyone who may have information on Annie's whereabouts is urged to contact Singleton Police Station on (02) 6578 7499 or Crime Stoppers on 1800 333 000.