UPDATE: The New England Highway has re-opened after this morning's crash south of Tamworth.
A man who was trapped in a vehicle was airlifted to Tamworth Hospital in a serious condition by the Westpac Rescue Helicopter, while a woman in the second vehicle was transported by ambulance to Tamworth Hospital in a serious condition.
Crash investigators examined the scene before both vehicles were towed and the scene cleared.
Full details in tomorrow's edition of The Leader.
EARLIER: The New England Highway has been closed after a head on crash, 25km south of Tamworth this morning.
Emergency services including ambulance rescue paramedics and police rushed to the scene near Goonoo Goonoo Station just before 8.30am on Tuesday, after reports of a two car collision.
Rescue paramedics are working to free a man trapped in one of the vehicles, while paramedics are assessing a woman in the second vehicle who has serious injuries.
The Westpac Rescue Helicopter has been tasked and is on scene with a doctor and paramedic, waiting to transport one patient.
Police and RMS crews are also on scene and diversions are now in place, with the road expected to be closed for some time as crash investigators examine the site.
Southbound motorists are urged to take Burgmann's Lane, onto Werris Creek Rd, while northbound motorists should turn at Maria St at Wallabadah.
Both diversions are suitable for heavy vehicles.