A two-time semi-final loser at Melbourne Park, Tsitisipas takes on world No.2 Daniil Medvedev on Friday night hoping it's third time lucky in his latest final-four showdown.

Last year the pair met at the same stage with the Russian toppling Tsitsipas 6-4 6-2 7-5.

In the quarter-finals, Tsitsipas thrashed rising Italian Jannik Sinner 6-3 6-4 6-2 in comfortably his best match of the 2022 Open.

"So far it has been the most consistent and the best match I've had in the tournament," said the world No.4.

"I feel like I'm in the zone - I have no plans of getting out of it - it's part of my game."

Having taking over the deported Djokovic as the top-ranked player in the tournament, Medvedev has the opportunity to live up to that lofty billing and set a new mark along the way.

The 2021 US Open champion is attempting to become the first man in the 55-season Open era to win his second major title in his next grand slam appearance

With a spicy history between the young pair, 23-year-old Tsitsipas could take some sweet revenge with a victory.

At the ATP Masters in Miami in 2018, they exchanged heated words at the net following the Russian's victory.

"It's fine," said Tsitspias of the rivalry.

"We haven't really spoken in the past couple of months, but our relationship is competitors on the court and kind of fighting for the same dream."

While Medvedev has a 6-2 win-loss record against Tsitsipas, the Greek has claimed two of their past three encounters, including a quarter-final clash last year at Roland Garros.

Tsitispas then surrendered a two-sets-to-love advantage over Djokovic in the French Open final.

Stung by that shattering defeat, Tsitsipas said he would be ready for anything on Rod Laver Arena.

"You never know what you're going to get," he said.

"Every match is different, and you need to be prepared for each and every battle no matter what your opponent is going to bring out there."

Following his four-hour, 42-minute semi-final battle to beat Felix Auger-Aliassime, Medvedev knows he must be able to back up to join the likes of Djokovic, Roger Federer and Rafael Nadal as a grand slam dominator.

"I'm feeling pretty confident - of course," the 25-year-old said.

"I don't know how my body will feel but hopefully I can recover well and be ready for the semis.

"I've never had this experience - I played some long matches but never like four hours and never won it to be able to play in two days.

"If we look at the best, they were able to do it somehow so if I want to be a part of this group.

"Even if I'm really far right now, I want to try to make it happen.

"I'm going to try to recover as well as possible, to be ready to play against Stefanos, because he's a great player and I need to be at my best to beat him."

Australian Associated Press