NSW Ambulance Duty Operations Manager Brian Lakin said the cause of the crash, which took place before 9am, was still under investigation.

He confirmed the three vehicles had run into each other "nose-to-tail" and said there was the "potential for inattention" in the crash.

Four patients were treated for minor injuries, and three taken to hospital as a precaution, he said.

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The injuries included neck pain, multiple abraisians and brusing. One female victim suffered some chest pain, which paramedics deemed to be a seatbelt injury.

The youngest victim was just five.

Paramedics took her to hospital, with her 30-year-old mum.

A spokesperson for Oxley Police confirmed the road had been closed for ease of access by NSW Ambulance for several minutes,

An Ambulance NSW spokesperson said none of the motorists were considered seriously injured.

One person was left uninjured by the crash.

It's the second time in two days the road has been blocked. On Tuesday, residents were trapped in the suburb after the Peel River burst its banks.

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