The operations starts at 12.01am on Friday, October 4 and finishes at 11.59pm on Monday, October 7.

Double demerits will be in force throughout the period for speeding, seatbelt, mobile phone and motorcycle helmet offences.

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Traffic and Highway Patrol Command's Assistant Commissioner Michael Corboy said along with school holidays, people were also embarking on long-haul drives to the NRL Grand Final and other events.

"These days are meant for families and friends to spend time together safely, so we are urging all motorists to plan ahead and manage their trips," Assistant Commissioner Corboy said.

"This means not driving while you are tired, remembering to take breaks, not driving too fast for the conditions and refraining from alcohol if you're getting behind the wheel.

"Lives are being lost on the roads and families are being changed forever because some motorists have not heeded the warning signs or taken necessary precautions."

Assistant Commissioner Corboy said the police force would be out in full force "working throughout this long weekend to ensure people get to and from their long weekend destinations safely".

Attorney General and Acting Minister for Police and Emergency Services Mark Speakman said drivers, riders, cyclists, and pedestrians needed to consider their own behaviour on the roads to keep themselves, their families, and other road users safe.

"Driving under the influence of drugs or alcohol, speeding, not wearing a seat belt or getting distracted could end in tragedy this weekend, so don't risk your life, or the lives of others, over something stupid," Mr Speakman said.

Minister for Regional Transport and Roads Paul Toole said speeding, driving under the influence and fatigue were the biggest killers on NSW roads.

"We need all motorists to play their part in keeping our road toll down. Don't take a risk that you may regret for life," Mr Toole said.

"As our clocks tick forward an hour for daylight savings, we're reminding motorists to make sure their kilometres don't tick forward too and if you're planning on watching the Roosters and the Raiders battle it out during the Grand Final, make sure you have a Plan B.

During the 2018 Operation Slow Down period, five lives were lost in four fatal crashes on NSW roads.