RISKY drivers on regional roads will be targeted by police under Operation Chrome.
The statewide action will see highway patrol and general duties officers out in force from Friday through Sunday.
Those doing the wrong thing should expect to be caught, Peel Highway Patrol Senior Sergeant Mick Buko said.
"I would like to see no drink-driving and nobody caught, but we will catch people drink-driving still," he said.
"The same goes for driving under the influence of drugs, we need to eradicate that."
Officers will target back roads in Tamworth and smaller towns like Gunnedah and Moree at the weekend blitz.
Double demerits won't be enforced, but new drink-driving laws mean drivers can have their licences disqualified on the spot for low-range offences.
Extra highway patrol police will be on duty, combined with general duties officers from the districts and an influx of specialist police out in force, Sergeant Buko said.
"A few weeks ago we saw someone arrested in Peel Street for drink-driving," he said.
"I think people forget if they finish drinking at 2am and want to go for breakfast and a drive, they can still be well over the limit.
"There's an eight to 10-hour window after a big night where people can still affected by alcohol.
"If they take the chance now with the drink-driving laws, they will lose their licence on the spot and that can have serious effects on their lives and work."
A blitz in May under the same operation saw police arrest 10 people and issue 59 infringement notices to risky drivers in the Oxley and New England police districts.
Operation Chrome officially launched in Bathurst on Thursday.
Reducing road trauma was one of the most important roles and responsibilities for officers, NSW Police Commissioner Michael Fuller said.
"There's been 166 lives lost this year in regional NSW, that's 20 up from last year," he said.
"That's potentially 166 children orphaned, 166 communities that will never be the same.
"And most of these are preventable deaths."
Operation Chrome begins on Friday and police will continue extended patrols until Sunday.