It’s believed the crash occurred in the early hours of Saturday on Cypress Way at Gwabegar, 10km out of the village towards Pilliga.

Ambulance NSW said the first call was received about 5.10am after a man was found laying on the side of the road, conscious and breathing.

Police said an 18-year-old was also found down the road attempting to find help following the crash.

Two ambulance units as well as the Westpac Rescue Helicopter from Tamworth was tasked to the scene.

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A man, aged 20, was airlifted to John Hunter Hospital in Newcastle and was believed to be in a critical condition.

The second man, 18, was taken to Narrabri hospital by ambulance.

He was believed to be in a stable condition and suffered minor injuries in the crash, police said.

Oxley police set up a crime scene with forensic officers from Tamworth deployed to the crash site to comb the area.

The cause of the crash is under investigation.

Anyone with information or who may have dashcam footage is urged to contact police.